Effect of soy isoflavones on acne vulgaris

To demonstrate the effect of soy isoflavones on acne vulgaris [AV] lesions in female patients. In this randomized pretest-posttest control group design, 25 patients were randomized into 5 groups: isoflavones 40 mg, 80 mg, 120 mg, 160 mg and placebo, and treated for 4 weeks. The mean total AV lesions before treatment among the five groups was similar [p=0.259], whereas after treatment significant difference was observed [p=0.001]. Intergroup comparison revealed that decrease in the mean total AV lesion count before and after treatment was significant in isoflavone 160 mg group [p>0.05]. Soy isoflavones supplementation 160 mg/day can lower total AV lesion